Official websites use. Share sensitive information only on official, secure websites. Corresponding author: Kathleen M. Schmeler, MD. Phone Fax All authors approved the final version of the manuscript. KMS is the guarantor of the paper. To estimate the prevalence of anal dysplasia in women with high-grade dysplasia or carcinoma of the cervix, vagina or vulva.
Patients with HSIL high-grade squamous cell intraepithelial lesion or greater on anal cytology or anal biopsy were referred to a colorectal surgery specialist for further evaluation. Seventy-five women were enrolled in the study, including 47 with cervical cervix group , 10 with vaginal vagina group , 15 with vulvar vulva group , 1 with cervical and vaginal, and 2 with vulvar and vaginal disease. The median age in the cervix group 40 years range 26β69 was substantially younger than in the vagina 60 years 38β69 and the vulva 59 years groups.
Anal HSIL based on composite endpoints of the most severe cytology or histology result was diagnosed in 6 patients 8. Anal cytology revealed HSIL in 2 2. No case of anal cancer was observed. To further support the inclusion of this high-risk group into screening guidelines for anal dysplasia, further studies are necessary to determine what screening strategy is suited to this population.
Keywords: prevalence, anal dysplasia, vaginal dysplasia or cancer, vulvar dysplasia or cancer, cervical dysplasia or cancer, anal screening. Persistent high-risk human papillomavirus hrHPV infection is the primary cause of cervical cancer, and has also been linked to the occurrence of vulvar and vaginal cancers 1 , 2.
There is a growing body of evidence suggesting that the natural history of HPV-induced anal cancer is close to that of cervical cancer 5. While primary anal HPV infection may occur with ano-receptive intercourse, pooling in the posterior vagina, and front-to-back dabbing and wiping behavior can facilitate virus extension to the anus in women 1 , 3.
